Here are the collective resumes of the potential 1-seeds using ESPN's RPI #s. I excluded Kentucky because they are a lock.
UVA: 5-2 vs. top 25, 8-2 vs. top 50, 15-2 vs. top 100; losses are to #4 Duke and @ #14 Louisville; SOS #25
Duke:: 6-1 vs. top 25, 10-2 vs. top 50, 17-3 vs. top 100; losses are @ #24 ND, @ #43 NCSU and vs. #60 Miami; SOS #14
Wisky: 2-2 vs. top 25, 7-2 vs. top 50, 14-2 vs. top 100; losses are vs. #4 Duke, @ #9 MD, and vs. #164 Rutgers; SOS #21
Arizona: 3-0 vs. top 25, 6-0 vs. top 50, 13-2 vs. top 100; losses are @ #84 ASU, @ #100 UNLV and @ #114 OSU; SOS #46
Nova: 6-1 vs. top 25, 11-1 vs. top 50, 16-2 vs. top 100; losses are @ #21 GTown and @ #81 Seton Hall; SOS #45
I think it's pretty clear that the 1-seeds right now are Kentucky, UVA, Duke and Nova in some order. Wisconsin and Zona are pretty far behind when it comes to top 25 wins. They would definitely need to run through their conference tourneys without a loss and then they're in the conversation.
UVA: 5-2 vs. top 25, 8-2 vs. top 50, 15-2 vs. top 100; losses are to #4 Duke and @ #14 Louisville; SOS #25
Duke:: 6-1 vs. top 25, 10-2 vs. top 50, 17-3 vs. top 100; losses are @ #24 ND, @ #43 NCSU and vs. #60 Miami; SOS #14
Wisky: 2-2 vs. top 25, 7-2 vs. top 50, 14-2 vs. top 100; losses are vs. #4 Duke, @ #9 MD, and vs. #164 Rutgers; SOS #21
Arizona: 3-0 vs. top 25, 6-0 vs. top 50, 13-2 vs. top 100; losses are @ #84 ASU, @ #100 UNLV and @ #114 OSU; SOS #46
Nova: 6-1 vs. top 25, 11-1 vs. top 50, 16-2 vs. top 100; losses are @ #21 GTown and @ #81 Seton Hall; SOS #45
I think it's pretty clear that the 1-seeds right now are Kentucky, UVA, Duke and Nova in some order. Wisconsin and Zona are pretty far behind when it comes to top 25 wins. They would definitely need to run through their conference tourneys without a loss and then they're in the conversation.